中文摘要：

取代苯甲醛与取代2-羟基苯乙酮缩合形成α,β-不饱和酮（4a-4 f）;4用H2O2氧化关环制得取代-3-羟基-2-取代苯基色酮（5a-5 f）;5与2-氯-5-氯甲基吡啶反应合成了6个新型的含二氯五氯甲基吡啶结构的色酮类衍生物（6a-6 f）,其结构经1H NMR,13C NMR和元素分析表征。初步体外活性实验结果表明,部分化合物具有较好的抗胃癌细胞（SGC-7901）活性。

英文摘要：

α,β-Unsaturated ketones（4a~4f） were preparated by the condensation reaction of substituted benzaldehyde with substituted-2-hydroxyacetophenone.Six novel chromene derivatives（6a~6f） containing 2-chloro-5-chloromethylpyridine moiety were synthesized by the reaction of 2-chloro-5-chloromethylpyridine with substituted3-hydroxy-2-substituted-phenyl chromone（5a~5f）,which were preparaed by the cyclization of 4 using H2O2 as the oxidant.The structures of 6 were caracterized by 1H NMR,13C NMR and elemental analysis.The preliminary in vitro assay tests showed that some compounds exhibited certain activity against human gastric cancer cell SGC-7901.