中文摘要：

Bioengineered 角膜是为被设计治疗影响眼睛的表面的严重疾病的人的施主织物的代用品。然而，为生物工程学角膜的候选人种子房间的缺乏仍然是一个问题。骨头髓间充质的干细胞(MSC ) 能够多行的年龄区别。因此，我们决定了 MSC 是否区分进角膜的上皮的房间(EC ) 。我们使用了三个 exoteric-microenvironmental 系统导致 MSC 成为 EC。导致的 MSC 借助于词法检查被识别，免疫细胞化学的分析，和流动式细胞测量术。在一微型环境种的 MSC 有角膜的上皮的祖先的类似于那些的特征。导致的 MSC 为 EC 表示了标记，包括 integrinbeta 1， C X 43， Pax6，和 P63。MSC 成功地被导致成为角膜的上皮的祖先。因此， MSC 的使用可以为重建保持实质的诺言在角膜的损害以后的眼睛的表面。

英文摘要：

Bioengineered corneas are substitutes for human donor tissue that are designed to treat severe disease affecting ocular surfaces. However, a shortage of candidate seed cells for bioengineering corneas is still a problem. Bone-marrow mesenchymal stem cells （MSCs） are capable of multilineage differentiation. Therefore, we determined whether MSCs differentiate into corneal epithelial cells （ECs）. We applied three exoteric-microenvironmental systems to induce MSCs to become ECs. Induced MSC were identified by means of morphologic examination, immunocytochemical analysis, and flow cytometry. MSCs grown in one microenvironment had characteristics similar to those of corneal epithelial progenitors. Induced MSCs expressed markers for EC, including integrin 61, Cx43, Pax6, and P63. MSCs were successfully induced to become corneal epithelial progenitors. Therefore, the use of MSCs may hold substantial promise for reconstructing the ocular surface after corneal injury.