中文摘要：

流行病学研究表明牙周病和动脉粥样硬化存在一定相关性。牙龈卟啉单胞菌是牙周炎中的口腔常驻菌和主要致病菌。可入侵内皮细胞，导致内皮细胞功能障碍和血管平滑肌细胞在内膜上的增殖和迁移，巨噬细胞渗透性增强，炎性细胞因子水平升高，促使巨噬细胞吞噬脂质形成泡沫细胞，脂质在动脉血管壁的积聚从而引起斑块的破裂并发生血栓形成以及其他促进致动脉粥样硬化体征的出现。现分别通过动物模型实验和体外研究就牙龈卟啉单胞菌在动脉粥样硬化发生发展过程中可能存在的作用机制做一综述。

英文摘要：

Links between periodontal diseases and atherosclerosis have been well documented by epidemiological studies. Porphyromonas gingivalis is the main pathogenic bacteria and oral resident bacteria. It invaded endothelial cell to induce dysfunction of endothelial cell and proliferation and migration of vascular smooth muscle cells in the intima, enhanced macrophage infiltration, elevated levels of inflammatory marks, lipid accumulation in the arterial wall, foam cell formation, and advances in other proatherogenic signs. This article reviewed the possible pathogenesis mechanisms of Porphyromonas gingivalis in the development of atherosclerosis by animal model experiments and in vitro studies.