中文摘要：

含有不同取代基的（E）-2-（苯并噻唑-2-基）-3-（2-羟基苯基）丙烯腈与亚磷酸二苯酯在水中，无催化剂催化即可发生Michael加环／环化串联反应，可以高产率地生成相应的[2-氨基-3-（苯并噻唑-2-基）-4胁色烯-4-基]膦酸酯衍生物．同时，也尝试了水杨醛、2-（苯并噻唑-2-基）乙腈和亚磷酸二苯酯在Et3N催化下的三组分一锅法反应合成相应的膦酸酯衍生物．

英文摘要：

A series of （2-amino-3-（benzothiazol-2-yl）-4H-chromen-4-yl）phosphonate derivatives were synthesized in good to excellent yields by Michael addition/cyclization of diphenyl phosphite to diverse substituted （E）-2-（benzothiazol-2-yl）-3-（2- hydroxyphenyl）acrylonitriles under catalyst-free condition in water. Meanwhile, one-pot three component reaction of salic- ylaldehyde, 2-（benzothiazol-2-yl）acetonitrile and diphenyl phosphate was also tested using Et3N as catalyst to synthesize these phosphonate derivatives