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中文摘要：
类风湿关节炎（RA）是一种常见的自身免疫性疾病，其发病机制涉及细胞因子、遗传和感染等多种因素，前列腺素E2（PGE2）是RA发生发展过程中重要的炎性介质之一，细胞因子如白细胞介素1（IL-1）和肿瘤坏死因子α（TNF—α）在RA的骨损伤中起重要作用。为阐明RA的发生机制和寻找更安全有效的治疗药物提供参考，现就PGE2和IL-1在RA发生中的作用、PGE2及其相关因素和IL-1的关系及治疗RA的药物作用机制研究作一概述。
英文摘要：
Rheumatoid arthritis （RA） is a common autoimmunity disease. Many effective factors including cytokines, heredity and infection contribute to the pathogenesis process of RA. Prostaglandin E2 （ PGE2 ） is one of major inflammatory mediators. Cytokines such as interleukin-I （ IL-1 ） and tumor necrosis factor α （TNF-α） play important roles in the pathogenesis of bone loss associated with RA. This article clarifies the mechanism of PGE2 and IL-1 in pathogenesis of the RA and the relationship of PGE2 and its related factors to IL-1 as well as the pharmacological mechanism of drug used in the treatment of RA.
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