中文摘要：

Pederin 属于在陆上的甲壳虫和海洋的海绵发现的一组反肿瘤混合物。它被粗纱甲壳虫 Paederus 的一些成员显然对食肉动物用作化学防卫。通常认为的 pederin 生合成基因(ped ) 的最近的簇分析强烈建议 pederin 被细菌的共生者生产。这篇论文为证明简历的 symbiontic 起源是活跃代谢物考察了标准，为 pederin 的间接、分子的证据 ped 簇的细菌的起源和 pederin 的通常认为的生合成过程。

英文摘要：

Pederin belongs to a group of antitumor compounds found in terrestrial beetles and marine sponges. It is apparently used by some members of the rove beetle Paederus as a chemical defense against predators. A recent cluster analysis of the putative pederin biosynthesis gene （ped） strongly suggests that pederin is produced by bacterial symbionts. This paper reviewed the criteria for proving symbiontic origin of bioactive metabolite, indirect and molecular evidences for pederin bacterial origin, as well as three sets ofped clusters and putative biosynthesis process of pederin.