中文摘要：

MicroRNA是一类长度约为18-24nt的非编码小RNA,它在转录后水平通过调控靶基因来行使多种生物学功能,例如：细胞周期、分化、细胞增殖和凋亡等。在转录水平,转录因子作为一种重要的调控因子参与调控多种基因的表达。近些年研究表明转录因子可以直接调控miRNA的表达,并且参与了包括肿瘤疾病发生等多种生物学进程。转录因子与miRNA形成的调控网络已被广泛地研究,文中就目前已有的研究成果进行综述,以期为今后转录因子与miRNA调控通路的研究提供一定的理论基础。

英文摘要：

MicroRNAs （miRNAs） are a class of short non-coding RNAs of 18 to 24 nucleotides in length that post-transcriptionally regulate various target genes which involving in a variety of biological processes such as cell cycle,differentiation, cell proliferation, and apoptosis, At the transcriptional level, transcription factors （TFs） has been considered as the primary regulator to control the gene expression. Recent studies show that transcription factors regulate the expression of miRNA,and participate in a variety of biological processes including tumorigenesis. The regulatory network of TF-rniRNA has been studied widely,and this paper reviews the recent research findings. It＇s hoped to provide a theoretical basis for study of regulatory pathway of TF-miRNA in the future.