中文摘要：

目的：探讨不同分子亚型乳腺浸润性导管癌组织中Sox2与Oct4蛋白的表达及意义。方法：根据癌组织ER、PR、HER-2的表达情况将120例乳腺浸润性导管癌分型为LuminalA45例、LuminalB29例、HER-2过表达27例和Basal-like19例。采用免疫组化SP法检测不同分子亚型乳腺浸润性导管癌组织中Sox2与Oct4蛋白的表达。结果：4种分子亚型乳腺浸润性导管癌组织中Sox2与Oct4蛋白的表达比较,差异有统计学意义（H=27.688和50.737,P〈0.001）;Basal-like型乳腺浸润性导管癌组织中Sox2与Oct4蛋白的表达高于其他3种类型,LuminalA型低于其他3种类型（P〈0.05）。乳腺浸润性导管癌组织中Oct4与Sox2的表达相关（rS=0.506,P〈0.001）。结论：肿瘤干细胞标志物Sox2与Oct4蛋白的表达可能与乳腺浸润性导管癌的生物学行为密切相关。

英文摘要：

Aim：To investigate the expressions of tumor stem cell markers Sox2 and Oct4 in different molecular sub- types of breast invasive intraductal cancer. Methods ：The expressions of Sox2 and Oct4 protein in 120 cases of breast inva- sive intraductal cancer （ Luminal A 45 cases, Luminal B 29 cases, HER-2 overexpression 27 cases, Basal-like 19 cases） tis- sues were detected by immunohistochemistry SP method. Results：The positive expression rates of Sox2 and Oct4 protein a- mong the 4 groups had significant differences （H = 27. 688,50. 737, P 〈 0.001 ）, which were much higher in Basal-like breast cancer tissue and much lower in Luminal A breast cancer tissue（P 〈 0.05 ）. There was positive relationship between the expressions of Sox2 and Oct4 in breast invasive intraductal cancer tissue（ r = 0. 506 ,P 〈 0. 001 ）. Conclusion ： The ex- pressions of Sox2 and Oct4 are closely correlated with the clinical manifestations of molecular subtypes of breast invasive in- traductal cancer .