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Two pairs of chlorine-containing phenylpropanoid enantiomers from Acorus tatarinowii
  • ISSN号:1001-8417
  • 期刊名称:《中国化学快报:英文版》
  • 时间:0
  • 分类:TQ246.37[化学工程—有机化工] Q949.717.2[生物学—植物学]
  • 作者机构:[1]Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China, [2]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China, [3]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China, [4]College of Life Science, Hubei University, Wuhan 430062, China
  • 相关基金:Acknowledgments The authors would like to thank the Analytical and Testing Center at Huazhong University of Science and Technology for assistance in conducting ECD and IR analyses. This work was financially supported by the Program for New Century Excellent Talents in University, State Education Ministry of China (No. NCET- 2008-0224), the National Natural Science Foundation of China (Nos. 31370372, 81573316, 31570361, 31200258).
中文摘要:

二包含氯的 phenylpropanoid enantiomers (1a/1b 和 2a/2b ) 从 Acorus tatarinowii 的根茎被孤立。有趣地,这些光异构体(1a/1b 和 2a/2b ) 在一样的工厂被共存,它从类 Acorus 作为第一个包含卤素的自然产品被描绘。他们的结构和绝对配置被分光镜的分析和单个水晶的 X 光检查衍射的联合阐明,由一个修改 Moshers 方法帮助了。phenylpropanoid 异构体(1a/1b 和 2a/2b ) 与五根人的癌症房间线用 DPPH 试金和细胞毒素的活动为他们的抗氧化剂活动被作比较。

英文摘要:

Two pairs of chlorine-containing phenylpropanoid enantiomers(1a/1b and 2a/2b) were isolated from the rhizomes of Acorus tatarinowii. Interestingly, these optical isomers(1a/1b and 2a/2b) were co-existed in the same plant, which were characterized as the first halogen-containing natural products from the genus Acorus. Their structures and absolute configurations were elucidated by a combination of spectroscopic analysis and a single-crystal X-ray diffraction, assisted by a modified Mosher's method. The phenylpropanoid isomers(1a/1b and 2a/2b) were evaluated for their antioxidant activities using DPPH assay and cytotoxic activities against five human cancer cell lines.

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期刊信息
  • 《中国化学快报:英文版》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:中国化学会
  • 主编:
  • 地址:北京市先农坛街1号
  • 邮编:100050
  • 邮箱:cclbj@imm.ac.cn
  • 电话:010-63165638
  • 国际标准刊号:ISSN:1001-8417
  • 国内统一刊号:ISSN:11-2710/O6
  • 邮发代号:2-915
  • 获奖情况:
  • 1998、1999年获中国科协和国家自然科学基金,高科技学术期刊资助二等奖,2000年获国家自然基金委重点期刊一等奖
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  • 被引量:760