中文摘要：

目的：观察额尔敦-乌日勒对动脉粥样硬化消退的影响,并检测相关炎症因子,探讨其作用机制。方法：用高胆固醇喂养方法复制家兔动脉粥样硬化模型,并予额尔敦-乌日勒干预治疗12w。于实验结束时检测血清中总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HLD-C）和血清中炎性标志物高敏C反应蛋白（hs-PCR）含量,以及血管细胞粘附分子-1（VCAM-1）的水平;观察各组家兔主动脉动脉粥样硬化情况;检测主动脉中VCAM-1 mRNA表达水平。结果：与自然消退组比较,额尔敦-乌日勒治疗组的血清TC、TG、LDL-C水平降低,HLD-C变化不明显;主动脉斑块面积占总面积的百分比及内膜/中膜厚度比减小;血清中hs-PCR含量和VCAM-1水平降低,主动脉VCAM-1mRNA表达水平下降。结论：额尔敦-乌日勒对早期动脉粥样硬化具有消退作用,其机制可能与降脂、抗炎有关。

英文摘要：

The study is aimed to observe the effect of Eerdun-wurili on atherosclerosis recession.Related inflammation factors were detected in the mechanism discussion.High cholesterol feeding method was used in the rabbit atherosclerosis model establishment.Eerdun-wurili was used in a 12-week treatment.Content of serum total cholesterol（TC）,triglycerides（TG）,low-density lipoprotein cholesterol（LDL-C）,high-density lipoprotein cholesterol（HLD-C）,and serum inflammatory markers hypersensitive C-reactive protein（hs-PCR） were detected after the experiment.Level of vascular cellular adhesive molecular-1（VCAM-1） was also tested.The aortic atherosclerosis severity was observed.The VCAM-1 mRNA expression level in the aorta was also observed.The results showed that compared with natural recession group,level of serum TC,TG,LDL-C in the treatment group were reduced.The content change of HLD-C was not significant.The percentage of aortic plaque area in total area and the ratio between inner-membrane and tunica media were also decreased.Serum hs-PCR content and VCAM-1 level were reduced.VCAM-1mRNA aortic expression level was also declined.It is concluded that Eerdun-wurili plays a recession role in early atherosclerosis.Its mechanism may be related to cholesterol-lowering and anti-inflammation.