中文摘要：

目的：检测人类肝细胞肝癌（HCC）中转移相关基因1（MTA1）表达的水平,研究该基因是否与肝癌肝切除术后患者的生存率及肿瘤复发相关,是否可以作为判断预后的指标。方法：利用实时荧光定量聚合酶链反应（real-time PCR）和免疫组织化学（IHC）的方法以人正常肝组织为对照,分别检测肝癌切除术后所得的肿瘤组织及相应的癌旁组织中MTA1的表达水平,通过Kaplan-Meier曲线研究不同MTA1表达水平与HCC患者生存率及复发率之间的关系。结果：MTA1在肝癌组织及癌旁肝硬化组织中的转录表达明显高于正常组织（P〈0.01）,同时,MTA1蛋白在肝癌组织及癌旁肝硬化组织中的表达也明显高于正常组织（P〈0.01）。通过Kaplan-Meier曲线及Log-rank检验证明MTA1能够影响肿瘤的复发及患者的生存期。结论：MTA1可以作为判断肝癌肝切除术后肿瘤复发及患者生存率预测的指标。

英文摘要：

Objective：To investigate the expression of metastasis associated 1（MTA1） in human hepatocellular carcinoma（HCC） and adjacent tissues,and its correlation with survival and recurrence,to consequenthy determin whether MTA1 is a suitable prognostic index for prognosis or not.Methods：The transcription and translation of MTA1 gene in HCC tissue,corresponding adjacent tissue,and normal tissue samples were determined by quantity real-time PCR and immunohistochemistry（IHC）,and the correlation between MTA1 and survival and recurrence of HCC patients was analyzed by Kaplan-Meier curve followed by log-rank test.Results：The transcription and translation of MTA1 gene were significantly higher in the HCC tissues and the adjacent cirrhotic tissues compared to the normal liver tissues（P〈0.01）.Expression level of MTA1 was related to survival and recurrence rates of the HCC patients.Conclusion：MTA1 was a suitable prognostic index predicting survival and recurrence after surgical resection of HCC.