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活血化淤汤对超声乳化白内障吸除术后黄斑区的保护作用

ISSN号：1672-5123
期刊名称：《国际眼科杂志》
时间：0
分类：R775[医药卫生—眼科;医药卫生—临床医学]
作者机构：[1]青岛大学医学院附属医院眼科,中国山东省青岛市266003
相关基金：基金项目：中国山东省中医药科技发展计划项目资助（No.2009-177）

作者：林静[1], 赵桂秋[1], 马岩[1], 王青[1], 杨珊珊[1], 胡丽婷[1], 车成业[1], 姜楠[1], 张京芬[1]

关键词：活血化淤汤, 超声乳化白内障吸除术, 黄斑水肿, 光学相干断层扫描, huoxuehuayu decoction, phacoemulsification, macular edema, optical coherence tomography

中文摘要：

目的：探讨活血化淤汤对超声乳化白内障吸除术后黄斑区的保护作用.方法：单纯年龄相关性白内障患者130例140眼分为A,B两组,A组80眼常规超声乳化吸除术;B组60眼行超声乳化吸除术后给予活血化瘀汤口服两个疗程,A,B两组分别于术前、术后1d;1,2,4,6,8wk及3mo观察最佳矫正视力、角膜及房水情况、黄斑中心凹视网膜厚度及黄斑区组织变化情况.结果：术后3mo,B组视力≥1.0的比例明显高于A组,差别有统计学意义.术后1wk,B组房水轻度闪辉比例明显低于A组,差别有统计学意义.术后1,2,4,6,8wk;3mo白内障超声乳化术后出现中心注视点厚度增加,A,B两组术后2～8wk与术前比较差异均有统计学意义;其中A组11 眼（13.7%）出现术后黄斑水肿,均发生于术后2～6wk,包括9眼中心凹增厚及2眼黄斑囊样水肿,其中7眼3mo内水肿消失;B组2眼（3.3%）出现术后黄斑水肿,包括1眼中心凹增厚及1眼黄斑囊样水肿,发生于术后4~6wk,到术后3mo水肿消失.术后2~8wk,B组中心凹厚度低于A组,差异有统计学意义.结论：白内障超声乳化术后黄斑部呈现厚度增加的趋势,造成一定程度的视力下降,少数人会出现黄斑囊样水肿,术后口服中药活血化瘀汤后视力≥1.0的比例明显提高,黄斑中心凹的厚度及黄斑水肿的发生率大大降低,提示了活血化瘀汤对超声乳化白内障吸除术后黄斑区的保护作用.

英文摘要：

AIM： To investigate the protective effect of huoxuehuayu decoction on macula after phacoemulsification. Into A, B groups. The 80 eyes of A group were treated by conventional phacoemulsification; the patients （60 eyes） of B group were given huoxuehuayu decoction orally for two courses after phacoemulsification. Best-corrected visual acuity（BCVA）, corneal and aqueous conditions ,thickness of macular central fovea and changes of macular retinal tissue in A, B groups were observed before surgery, 1 day; 1 week,2,4,6,8 weeks and 3 months after surgery. Was significantly higher than that of group A. One week after surgery the ratio of mild aqueous flare in group B was significantly lower than that of group A. The thickness of central fixation was significantly increased in both groups 1 week, 2, 4, 6, 8 weeks and 3 months after phacoemulsification; the difference between 2 to 8 weeks after surgery and pre-operation showed statistical significance in both groups. 11 eyes in A group had macular edema during 2 to 6 weeks after surgery, including 9 eyes with fovea thickened and 2 eyes with cystoid macular edema, and seven eyes＇ edema disappeared in 3 months. 2 eyes in B group had macular edema, including 1 eye fovea thickened and 1 eye cystoid macular edema, during 4 to 6 weeks after surgery, and the two eyes＇ edema disappeared 3 months after surgery. The fovea thickness in group B during 2 to 8 weeks after surgery was statistically lower than group A. Phacoemulsification.