中文摘要：

白细胞分化抗原147（CD147）/细胞外基质金属蛋白酶诱导因子（EMMPRIN）是一种跨膜糖蛋白,在肿瘤细胞表面广泛高表达,其主要作用是诱导成纤维细胞和内皮细胞产生基质金属蛋白酶,参与调控肿瘤细胞增殖、侵袭、转移、凋亡、血管生成、化疗耐药及能量代谢等。本文总结了CD147的生物学特性及其在肿瘤中的多种生物学功能和可能的调控机制。

英文摘要：

Cluster of differentiation 147（ CD147）/extracellular matrix metalloproteinase inducer（ EMMPRIN） is a widely distributed transmembrane glycoprotein that belongs to the immunoglobulin superfamily and is highly enriched on the surface of malignant tumour cells.A major function of CD147 is to stimulate matrix metalloproteinase production in stromal fibroblasts and endothelial cells.CD147 promotes growth,invasion,metastasis,and glycolysis of malignant cells,induces angiogenesis,multidrug resistance,and anoikis resistance,and inhibits starvation-induced autophagy et al.This review focuses on the structural and biological characteristics of CD147 as well as recent advances in its multiple functions in malignant tumours and underlining mechanisms.