中文摘要：

MiR-424是miR-16家族成员。近年研究表明miR-424与肿瘤的发生、发展及治疗预后密切相关。本文对miR-424在乳腺癌、宫颈癌、肺癌、肝癌及结直肠癌等多种肿瘤及白血病中的表达变化、作用及机制进行综述。研究发现miR-424的表达受多种因素的影响,miR-424可作为肿瘤诊断、分期、预后的生物标记物,可用于明确肿瘤范围,也可作为肿瘤的治疗靶物。

英文摘要：

A member of miR-16 family,miR-424 has been found to be closely related with tumorigenesis,tumor progrssion,prognosis and therapy. This article reviews the expression changes,roles and possible regulating mechanisms of miR-424 in leukemia and various tumors such as breast,cervical,lung,liver and colorectal cancers. Recent studies have demonstrated that the expression of miR-424 is affected by many factors,and miR-424 could be a biomarker of diagnosis,staging and prognosis in cancers,to identify the area of tumor,and be a target of therapy.