中文摘要：

translational 以后 O-GlcNAc 修正(O-GlcNAcylation ) 的动态变化被连接 O 的 -N-acetylglucosamine (O-GlcNAc ) 控制 transferase (OGT ) 和在房间的 glycoside hydrolase O-GlcNAcase (OGA ) 。O-GlcNAcylation 经常由 OGT 经由 O-GlcNAc 组的增加发生在丝氨酸(重量的单位) 和特定的底层蛋白质的 threonine (Thr ) 残余上。O-GlcNAcylation 是，这被知道了不仅通过各种各样的机制在癌症开发在许多基本细胞的过程，而且戏包含了一个重要角色。最近，积累数据在 histones 揭示那 O-GlcNAcylation 或 non-histone 蛋白质能导致随后的生物进程的开始，作为蛋白质代码或 histone 代码建议那 O-GlcNAcylation 可以提供识别平台或行政指令让蛋白质的随后的招募执行特定的函数。在这评论，我们总结 O-GlcNAcylation 和 epigenetic 变化的相互作用，介绍在 O-GlcNAcylation 和 epigenetic 之间的连接串音改变的最近的研究调查结果，并且在有在细胞内部的生物过程的 epigenetic 变化的 O-GlcNAcylation 的潜在的协作角色上推测。

英文摘要：

Dynamic changes of the post-translational O-GIcNAc modification （O-GIcNAcylation） are controlled by O-linked β-N-acetylglucosamine （O-GIcNAc） transferase （OGT） and the glycoside hydrolase O-GIcNAcase （OGA） in cells. O-GIcNAcylation often occurs on serine （Ser） and threonine （Thr） residues of the specific substrate proteins via the addition of O-GIcNAc group by OGT. It has been known that O-GIcNAcylation is not only involved in many fundamental cellular processes, but also plays an important role in cancer development through various mechanisms. Recently, accumulating data reveal that O-GIcNAcylation at histones or non-histone proteins can lead to the start of the subsequent biological processes, suggesting that O-GIcNAcylation as ＇protein code＇ or ＇histone code＇ may provide recognition platforms or executive instructions for subse- quent recruitment of proteins to carry out the specific functions. In this review, we summarize the interaction of O-GIcNAcylation and epigenetic changes, introduce recent research findings that link crosstalk between O- GIcNAcylation and epigenetic changes, and speculate on the potential coordination role of O-GIcNAcylation with epigenetic changes in intracellular biological processes.