中文摘要：

类固醇激素可以改善内淋巴积水和耳蜗循环功能、减轻内耳炎症水肿,是治疗内耳疾病比较公认且临床普遍应用的制剂。近年来经鼓室应用类固醇激素治疗内耳疾病以其给药后耳蜗淋巴液中药物浓度高、疗效可靠、副作用极少等优点,越来越受到重视。本文回顾了近十几年国内外学者关于经鼓室应用类固醇激素治疗梅尼埃病、突发性聋、耳鸣等疾病的相关文献,对鼓室内类固醇激素治疗的优势、疗效等进行综述。尽管目前最佳的药物类型、剂量、疗程、持续时间等都未确定,但经鼓室应用类固醇激素的前景十分乐观,是否可以成为全身激素治疗的一种替代疗法,仍需进一步深入的实验研究和调查。

英文摘要：

Corticosteroids can improve endolymphatic hydrops, cochlear circulation and relieve the inner ear inflammatory response. It is commonly accepted and recommended for treating inner ear disorders such as sudden idiopathic sensorineural hearing loss, Meniere disease and so on. In recent years, intratympanic steroid attracts more and more attention due to the advantage of high concentration of drugs in cochlear, reliable efficacy and minimal side-effects. This article reviews the published literature regarding the use of intratympanic steroids in the treatment of Meniere disease, sudden sensorineural hearing loss, tinnitus and so on. Although the best protocol for type of drugs, dosage and duration of intratympanic steroid is still uncertain, the perspective of clinical application is encouraging. More and high quality clinical studies are needed to determine if the intratympanic steroid treatment could replace the systemic steroids.