目的:探究麦粒灸疗法对非小细胞肺癌患者中性粒一淋巴细胞比率(neutrophit-lympho-cyteratio,NLR)及其生存质量的影响。方法:将70例非小细胞肺癌患者随机分为观察组和对照组,每组35例,最终观察组33例、对照组32例纳入统计。观察组选取足三里、肺俞予麦粒灸治疗,每穴9壮,每日1次,对照组不进行任何治疗,只进行追踪随访.试验持续6周,观察治疗前后两组患者中性粒一淋巴细胞比率及生存质量评分的变化并比较两组的差异。结果:治疗后相较于治疗前,观察组患者的中性粒一淋巴细胞比率明显降低(P〈0.05).总体健康状况/生命质量领域、躯体功能、情绪功能、认知功能、疲倦、疼痛、气促、失眠、食欲丧失明显改善(均P〈0.05);对照组患者治疗前后的中性粒一淋巴细胞比率、总体健康状况/生命质量领域、躯体功能、情绪功能、认知功能、角色功能、社会功能、疲倦、疼痛、气促、失眠、食欲丧失比较,差异均无统计学意义(均P〉0.05)。组间比较。观察组治疗后中性粒一淋巴细胞比率相较于对照组治疗后明显降低(P〈0.05),总体健康状况/生命质量领域、躯体功能、情绪功能、认知功能的评分较对照组治疗后有明显升高(均P〈0.05),疲倦、疼痛、气促、失眠、食欲丧失的评分较对照组治疗后有明显降低(均P〈0.05)。结论:麦粒灸疗法能够降低非小细胞肺癌患者的中性粒一淋巴细胞比率,改善其免疫功能,提高患者生存质量。
Objective To explore the impact on neutrophil--to-lymphoeyte ratio (NLR) and the quality of life (QOL) in the patients of non-small-cell lung cancer (NSCLC) treated with wheat-size moxibustion therapy. Methods Seventy patients of NSCLC were randomized into an observation group and a control group, 35 cases in each one. Finally, 33 cases were participated in the observation group and 32 cases in the control group for statisti- cal analysis. In the observation group, Zusanli (ST 36) and Feishu (BL 13) were selected for grain-size moxibus- tion, 9 moxa cones on each acupoint, once a day. There was the follow-up visit without any treatment applied in tile control group. The trial lasted for 6 weeks. The changes in NLR and the QOL score before and after treatment were observed in the patients of the two groups and the differences were compared between tile two groups. Results Compared with the condition before treatment, in the observation group, NLR was reduced apparently (P〈0.05), the general health state/life quality field, physical functioning, emotional functioning, cognitive functio- ning, fatigue, pain, short breath, insomnia and anorexia were improved apparently (all P〈0.05). In the control group, the differences were not significant in NLR, the general health states/life quality field, physical functio ning, emotional functioning, cognitive functioning, role functioning, social functioning, fatigue, pain, short breath, insomnia and anorexia before and after treatment (all P〉0.05). In comparison of the two groups, NLR was reduced apparently in the observation group as compared with that in the control group after treatment (P〈 0.05). The scores of the general health state/life quality field, physical functioning, emotional functioning and cognitive functioning were increased apparently as compared with those in the control group after treatment (all P〈0.05). The scores of fatigue, pain, short breath, insomnia and anorexia in the observation group were reduced a