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中文摘要：
异常学习记忆、应激与成瘾行为的发生及发展有着重要关系.本课题围绕与心理依赖相关的核心问题,推进和开创性地建立了与精神依赖相关的动物行为模型,在药物依赖及复吸等不同阶段,考察了成瘾相关的脑的奖赏环路、核团、递质、受体及不同亚型活性以及相关的基因调控等,对成瘾相关学习记忆的影响.探索了应激与负性情绪状态对成瘾行为发生及发展的影响.并应用基因芯片技术考察了重要的成瘾易感性相关基因序列在脑内的表达.
英文摘要：
Abnormal memory and stress play a key role on the development of addiction. Aiming at finding out the relationship between learning, memory and relapse of psychological active substances and its neurobiological mechanism, our efforts mainly concentrate on the brain mechanisms underlying morphine psychological dependence. Based on the modified and newly - made animal model measuring inborn behavioral character related to psychological dependence, we investigated the interaction between drug addiction and memory effects and the neurobiological mechanisms underlying the interaction during different phrase of drug addition, explored the effect of stress and negative emotion on the development and relapse of addiction, identified some genes responsible for individual risk for addiction with microarray technique.
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