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中文摘要：
β-arrestins是介导受体脱敏的重要的蛋白质家族，在G蛋白偶联受体的脱敏、内化和复敏中都有重要的作用。作为一类多功能的蛋白，β-arrestins对绝大多数由G蛋白偶联受体介导的信号通路有调节作用，并且参与调节一些非七次跨膜受体的信号转导。在多种恶性肿瘤中，β-arrestins通过调节G蛋白偶联受体或其他一些信号转导途径影响肿瘤细胞的增殖、侵袭和转移过程，参与了恶性肿瘤的病理过程。该文就βarrestins在恶性肿瘤发生发展过程中所起到的作用及目前的研究状况作一综述。
英文摘要：
β-arrestins are multifunctional adaptor proteins, which mediate desensitization , sequestration , and recycling of G pro-tein-coupled receptors （GPCRs）. Mounting evidence suggests that, in addition to regulation of GPCRs signals, β-arrestins also serve as modulators in a number of non-seven-transmembranes receptor-mediated signaling pathways. In a variety of malignant tumors, β-arrestins play an important role in proliferation, mi- gration and invasion of tumor cells by regulating GPCRs signals and other signaling pathways. β-arrestins also participate in the pathogenesis of malignant tumor. The role of β-arrestins in de- velopment of malignant tumor is reviewed in this paper.
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