中文摘要：

目的：评价抗苗勒管激素（AMH）对卵巢反应性的预测价值。方法：以1489例行体外受精-胚胎移植（IVF-ET）治疗的不孕患者作为研究对象,分别以获卵数≤3个和〉20个界定卵巢低和高反应,比较AMH和其他卵巢储备评估指标预测卵巢反应性时的受试者工作特征曲线面积（ROCAUC）。结果：预测卵巢低反应或高反应时,AMH和窦卵泡计数（AFC）的ROCAUC均相当（分别为0.867和0.860,P=0.319;0.772和0.753,P=0.287）,且明显大于年龄、基础卵泡刺激素（FSH）和基础雌二醇（E2）的ROCAUC（分别为0.685、0.723和0.600,P均〈0.001;0.679、0.650和0.501,P均〈0.001）。AMH≤8.5 pmol/L或AFC≤9时可较好地预测卵巢低反应,而AMH〉29.77 pmol/L或AFC〉16时则可较好地预测卵巢高反应。结论：AMH独立预测卵巢反应性的价值与AFC相当,二者均明显优于年龄、基础FSH和基础E2。

英文摘要：

Objective： To investigate the predictive value of anti-Müllerian hormone（ AMH） on ovarian response.Methods： A total of 1489 Chinese infertile women who underwent the first in vitro fertilization-embryo transfer（ IVF-ET） cycle were included in this retrospective study. Poor and high ovarian responses were defined as no more than 3 oocytes and more than 20 oocytes retrieved respectively. Receiver operating characteristic（ ROC）curves were made and area under curve（ AUC） were calculated to access the predictive power of AMH and other evaluation indexes on ovarian responses. Results： ROCAUCof AMH were almost the same as those of AFC when predicting poor or high ovarian response（ 0. 867,0. 860 respectively,P = 0. 319; 0. 772,0. 753 respectively,P =0. 287）,which were obviously higher than those of age,basic FSH and basic E2（ 0. 685,0. 723,0. 600 respectively,P〈0. 001; 0. 679,0. 650,0. 501 respectively,P〈0. 001）. Poor ovarian responder could be recognized when AMH was≤8. 5pmol / L or AFC was≤9. When AMH was 29. 77 pmol / L or AFC was 16,high ovarian response could be expected. Conclusions： AMH and AFC had greater value than age,basic FSH and basic E2 on prediction of ovarian responses independently.