中文摘要：

junctophilin是目前公认的可兴奋细胞的胞膜与内（肌）质网耦联的分子基础。其可能的作用机制是以C端锚定在内（肌）质网上，通过N端的MORN结构域（MORN motif）与细胞膜相互作用。目前已知该分子在哺乳动物中存在四种亚型，在骨骼肌和心肌分别以Jp-1和Jp-2为主。junctophilin的低表达会导致细胞膜与内（肌）质网脱耦联，从而使心肌和骨骼肌兴奋收缩耦联效率降低，进而影响收缩能力。目前已发现junctophilin基因突变与心衰等疾病有关，因而junctophilin可能成为针对这些疾病的药物开发新靶点。

英文摘要：

Junctophilin is a molecule that couples endo （sarco）plasma membrane to plasma membrane in excitable cells. Its C terminal anchors into the endo（ sarco）plasmic reticulum, while its N terminal interacts with plasma membrane via the MORN motifs. Mammalian junctophilin has four subtypes, among which Jp-1 and Jp-2 exist mainly in skeletal and cardiac muscle, respectively. In muscle cells, low expression of junctophilin decouples the sarcoplasmic reticulum from plasma membrane, decreases the efficiency of excitation-contraction coupling efficiency, and thereby compromises the contractility of heart and muscles. Many human diseases such as heart failure accompany with junctophilin mutations, so junctophilin may become a new target against these diseases.