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木立芦荟中BACE抑制活性成分的研究
  • 期刊名称：木立芦荟中BACE抑制活性成分的研究，高博，姚春所，方唯硕*等，药学学报，2006，41（10）：1
  • 时间：0
  • 分类：R284.1[医药卫生—中药学;医药卫生—中医学] R284.2[医药卫生—中药学;医药卫生—中医学]
  • 作者机构：[1]中国医学科学院、中国协和医科大学药物研究所中草药物质基础与资源利用教育部重点实验室,北京100050, [2]武汉大学药学院,湖北武汉430072
  • 相关基金：国家自然科学基金资助项目（20432030,30500647）. 致谢：核磁共振谱、质谱、红外光谱和紫外光谱由中国医学科学院、中国协和医科大学药物研究所分析测试中心代测;活性实验由中国医学科学院药物研究所国家药物筛选中心王月华老师代测.
  • 相关项目：高效快速新颖结构天然产物的发现及其生物活性研究
关键词： 木立芦荟, BACE抑制活性, 芦荟宁衍生物, Aloe arborescens, BACE inhibitory activities, aloenin derivatives
中文摘要：

目的从木立芦荟（Aloe arborescens）中寻找新的BACE（β-分泌酶）抑制活性成分。方法用硅胶正相色谱及反相色谱技术进行活性成分的分离纯化，根据理化性质、光谱资料进行结构鉴定。结果从木立芦荟95％乙醇提取物的乙酸乙酯部分和正丁醇部分，分离得到了8个化合物：异丁酰基芦荟宁A（1），芦荟宁A（2），芦荟大黄素（3），（E）-2-acetonyl-8-（2’-O-feruloxyl）-β-D-glucopyranosyl-7-methoxy-5-methyl-chromone（4），7-O-methyl aloeresin A（5），芦荟苷A（6），elgonica-dimerA（7）和elgonica-dimer B（8）。结论化合物1为新化合物，化合物4为首次从该植物中分离得到。活性测试结果表明，化合物2，4，5，6对BACE有一定的抑制活性。

英文摘要：

Aim To seek for new components as BACE inhibitors from Aloe arborescens. Methods The chemical constituents were isolated by chromatographic methods and their structures were elucidated on the basis of spectral analysis. Results Eight compounds were isolated and their structures identified as 6＇-O-isobutyryl aloenin A （ 1 ） , aloenin A （ 2 ） , aloe-emodin （ 3 ） , （E） -2-acetonyl-8- （ 2＇-O-feruloxyl ） -β- D-glucopyranosyl-7-methoxy-5-methyl-chromone （4） , 7-O-methylaloeresin A （ 5 ） , babarloin A （ 6 ） , elgonica-dimer A （7）, and elgonica-dimer B （8）, separately. Conclusion Compound 1 is a new compound, and compound 4 was isolated from A. arborescens for the first time. Pharmacological tests indicated that 2, 4, 5 and 6 have moderate inhibitory active on BACE.

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