骨形态发生蛋白2(BMP2)属于转化生长因子β(TGF-β)超家族成员,是一种分泌性蛋白,具有多重生物学功能。BMP2基因不仅可以诱导骨细胞的形成,还可以促进间充质干细胞向脂肪细胞分化,在脂肪的形成过程中发挥着重要作用。就该基因的结构、表达及其在诱导脂肪细胞形成方面的功能等进行综述。
Bone morphogenetic proteins (BMPs) belong to the transforming growth factor β (TGF-β) superfamily. It's a kind of secretory protein with multiple biological functions. Researches indicates that BMP2 not only can induce the formation of bone cells, but also can promote emesenchymal stem cells to adipocytes, and plays a critical role in the formation of fat. This review summarized recent research progresses in gene structure, expression and function of BMP2.