中文摘要：

近十年来,胶原三股螺旋重叠蛋白（CTHRC1）是一种备受瞩目的与肿瘤恶性生物学行为密切相关的蛋白.CTHRC1在多种实体肿瘤中均呈高表达,可促进肿瘤的迁移、侵袭,在部分肿瘤中可促进肿瘤的增殖能力.CTHRC1具有较多的生理功能,分子作用机制相对复杂.目前研究揭示了CTHRC1在肿瘤中的一些促癌的分子机制,然而其具体的机制仍不明确.本文就CTHRC1在肿瘤中的作用机制进行综述,为CTHRC1机制的进一步研究提供参考.

英文摘要：

Collagen triple helix repeat containing-1（ CTHRC1）has been a famous cancer related protein for the recent decade. It has been demonstrated that CTHRC1 is overexpressed in many kinds of solid tumors and plays an important role in promoting the ability of migration and invasive potential,in some cases,increasing the proliferation rate of tumor cells. CTHRC1 is a protein with multiple physiological functions and complicated molecular mechanisms. The existing researches have revealed some mechanisms of how CTHRC1 promotes the progression of tumor. Nevertheless,there is still much to investigate the exact mechanisms of CTHRC1 within tumors. In this review,we give an overview of the molecular mechanisms of CTHRC1 which have already been addressed by other researchers. The study aims to provide a reference for further research on CTHRC1.