中文摘要：

目的探讨乳腺癌患者化疗前后认知功能是否损害。方法采用成套的神经心理学测验分别对来自2012年1月至2013年2月在安徽医科大学第一附属医院就诊的42例化疗组乳腺癌患者（CT）进行化疗前（T1）和化疗后（T2）评定，和间隔时间相匹配的37例未化疗组乳腺癌患者（non—CT）以及40名健康对照组被试（HC）进行两次评定，比较3组被试神经心理学特征。结果与T1比较，化疗组患者在T2评估时，数字广度倒背（4．5±0．9）、数字符号[（48±8）分]、延迟记忆[（8．5±1．7）分]和再认回忆记忆[（7．9±1．6）分]的得分降低，完成TMT任务B（103±12）s、Stroop任务B（21．6±4．9）s及任务c（34．7±7．1）s时间延长，且差异均有统计学意义（分别为t=2．680、2．354、3．208、2．961-2．612、-2．600、-3．304；均P〈0．05）；3组被试在T2评估时，CT组、non-CT组及HC组得分分别在倒背测验为（4．5±0．9）分、（5．2±1．1）分、（5．3±1．1）分，数字符号为（48±8）分、（52±8）分、（51±8）分，延迟记忆测验为（8．5±1．7）分、（10．2±1．4）分、（10．5±1．8）分，再认回忆测验为（7．9±1．6）分、（9．8±1．6）分、（9．5±2．0）分；CT组、non．CT组及HC组分别在完成TMT任务B中为（103±12）s、（96±7）S、（97±8）S，Stroop任务B中为（21．6±4．9）S、（18．6±3．8）S、（18．2±2．7）s，Stroop任务C中为（34．7±7．1）s、（30．8±7，1）S、（29．8±6．2）S，化疗组患者的数字广度倒背、数字符号、延迟记忆和再认记忆得分少于未化疗组和健康对照组，完成TMT任务B、Stroop任务B及任务c时间慢于未化疗组和健康对照组，组间与时间交互效应显著，差异具有统计学意义（分别为F=3．272、3．202、8．851、7．789、4．524、5．641、4．201；均P〈0．05）。结论推测乳腺癌患者化疗后存在认知功能损?

英文摘要：

Objective To explore whether cognitive impairment in breast cancer patients after the completion of chemotherapy treatment in comparisons with breast cancer patients without chemotherapy treatment and matched healthy controls. Methods A neuropsychology battery was applied in all breast cancer patients at our hospital from January 2012 to February 2013. Forty-two breast cancer patients with chemotherapy treatment （CT） underwent neuropsychologic testing before the start of chemotherapy （ T1 ） and after treatment （T2）. And 37 patients without chemotherapy treatment （non-CT） and matched healthy controls （HC） underwent the same assessment at matched intervals. Results The CT group performed significantly worse on attention, memory and executive function tests at T2 versus T1 （ P 〈 O. 05 ）. As compared with HC and non-CT groups, the correct numbers of backward, digit symbol, delayed recall and recognition were lower in the CT group （ P 〈 0.05 ）. The reacting time of TMT test B, Stroop test B and Stroop test C were longer in the CT group （ P 〈 0.05 ）. There was significant time interaction in three groups （ P 〈 0.05 ）. Conclusion There are longitudinal changes in cognitive functioning of memory, attention and executive functions in breast cancer oatients on Chemotheraoy.