中文摘要：

象 Sindbis 一样病毒首先在 1986 在中国被发现。它的完全的染色体组的顺序由编码超过 3 的超过 11 000 bp 组成 700 氨基酸。它在一个非结构的区域包含 5 鈥?n on-transcriptional 区域(5 鈥?N TR ) ，四非结构的蛋白质(nsP1， nsP2， nsP3， nsP4 ) 区域，衣壳在保存；非保存的区域；结构的 E1， E2， E3， 6K 区域；3 鈥?n on-transcriptional 区域(3 鈥?N TR ) 。Sindbis-IMB 从怀疑有脑炎的一个病人的血被孤立，；被鉴定跟随；经过。病毒核糖核酸在感染的房间从病毒上层清液被提取；整个染色体被划分成 12 碎片；RT-PCR 然后被执行为完全的定序放大 12 碎片。结果证明 Sindbis-IMB 的整个染色体组的顺序由编码 3 的 11 717 bp 组成 773 氨基酸。象 Sindbis 一样孤立的与其它一起的相同比较证明最高的类似是有在云南省孤立的 1% 紧张的一个变化的 YN87448；第二最高与锝? 的一个变化拉紧到 SAAR86 2% 。核苷酸序列变化在非结构的区域是在场的，导致氨基酸 K， E， N， R， H，；在在位置的蛋白质序列的 L 230， 231， 443,781， 1 582，；1746 在新隔离分别地。而且，三另外的氨基酸—glutamic，丝氨酸；丙氨酸—作为与 YN87448 isolate 相比在 nsp4 终点被注意。

英文摘要：

The Sindbis-like virus was first discovered in China in 1986. Its complete genomic sequence consists of more than 11 000 bp encoding more than 3 700 amino acids. It contains a 5＇ non-transcriptional region （5＇-NTR） in a non-structural region, four non-structural proteins （nsP1, nsP2, nsP3, nsP4） regions, capsids in conserved and non-conserved regions and structural El, E2, E3, 6K regions and a 3＇ non-transcriptional region （3＇-NTR）. The Sindbis-IMB was isolated from the blood of a patient suspected to have encephalitis, and was followed by identification and passage. The virus RNA was extracted from virus supernatant in infected cells and the whole genome was divided into 12 fragments; RT-PCR was then performed to amplify the 12 fragments for complete sequencing. The results showed that the whole genomic sequence of Sindbis-IMB consists of 11 717 bp encoding 3 773 amino acids. Homology comparison with other Sindbis-like isolates demonstrated the highest similarity was the YN87448 with a variation of 1% strain isolated in Yunnan Province and the second highest to the SAAR86 strain with a variation of -1.2%. The nucleotide sequence variations were present in non-structural regions, resulting in amino acids K, E, N, R, H, and L in protein sequences in positions 230, 231,443,781, 1 582, and 1746 in the new isolation respectively. Furthermore, three additional amino acids-glutamic acid, serine and alanine-were noted in nsp4 terminus as compared to the YN87448 isolate