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中文摘要：
目的研究交联淀粉微球CSMs对阿司匹林的吸附性能，探讨引发剂用量、交联剂用量、反应温度和反应时间等因素对吸附量的影响规律。方法以CSMs为吸附载体，在阿司匹林乙醇溶液中进行吸附实验，测定相关参数。结果引发剂用量3g·L^-1时CSMs对阿司匹林的吸附量达到最大值；交联剂用量和添加方式在很大程度上决定了CSMs对阿司匹林的吸附和缓释性能；在一定范围内，温度升高，CSMs对阿司匹林的吸附量显著增大；反应初期，CSMs对阿司匹林的吸附量随反应时间的增加而急剧增加，在1．5h后趋于和缓。结论CSMs对阿司匹林有较高的载药量和包封率，可作为阿司匹林的吸附载体。
英文摘要：
Aim The adsorption behaviors of aspirin on CSMs were studied, discussing the influence of initiator and crosslinking agent dosage, reaction temperature and reaction time towards adsorption quantity. Methods The adsorption experiments were carried out in aspirin solution of ethanol using CSMs for carrier. Results The adsorption quantity of aspirin on CSMs reached maximum when 3g L^- 1 initiator. The adsorption and sustained release behaviors depended mainly on the dosage and adding method of crosslinking agent. The adsorption quantity of aspirin on CSMs increased significantly with increasing reaction temperature and time in a certain range. Conclusion CSMs may be used as one of drug carrier for aspirin due to its excellent drug loading and embedding ratio.
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