[目的]总结椎管内髓外肿瘤诊疗方法并分析其影响预后的相关因素。[方法]回顾性分析手术治疗168例椎管内髓外肿瘤患者,分析其影像学特点,并通过JOA评分评价临床疗效。评价患者病程、年龄、术前JOA评分与临床效果之间的关系。[结果]患者平均42岁(7—73岁),平均病程18.6个月(2—28个月)。肿瘤位于颈段者45例(28.7%),胸段者62例(39.5%),腰骶段者61例(38.9%),以神经鞘瘤和脊膜瘤为主,分别占53.6%、22.6%。随访时间为13—52个月,平均29.8个月,肿瘤完全切除160例(95.2%),部分切除8例(4.8%)。JOA评分:术前5—12分,平均7.6分,术后8—16分,平均13.8分,改善率为66.0%。依据Epstein标准:优150例,良10例,改善8例。患者病程、年龄与临床改善率呈负相关,相关系数分别为-0.353、-0.521,术前JOA评分与临床改善率呈正相关,相关系数为0.413。[结论]椎管内肿瘤临床疗效与病程、年龄、术前症状存在显著相关性。详细的病史采集、体检和影像学MRI检查是关键的诊疗手段。
[ Objective ] To summarize the experiences in management of intraspinal -extramedulary tumors. [ Methods ] The clinical characteristic, imaging examination and clinical effects of 168 patients with intraspinal - extramedulary tumors ad- mitted to our department for surgical treatment in the last 10 years were retrospectively analyzed. [ Results] In this group, the intraspinal tumors included neurinoma in 96 cases (53.6%) , meningiomas in 38 cases (22. 6% ), lipoma in 4cases (2.4%), metastasis tumor in 8 cases (4. 7% ), ganglioneuroma in 3cases (1.8%), hemangioma in 5 cases (3.0%), angiolipoma in 2 cases (1.2%) , arachnoid cyst in 1 case (0.6%) , epidermoid cyst in 8 cases (4.8%) , dermoid cyst in 4 cases (3.6%) , teratoma in 4 cases (2. 4% ) . According to the locations, 45 cases (28.7%) located at cervical region, 62 cases (39. 5% ) at thoracic region, 61 casess (38. 9% ) at lumbar and sacral region. All the patients in this group underwent operative treat- ment. 160 cases ( 92. 5% ) were totally resected, 8 cases ( 4. 8% ) were subtotally resected. Postoperatively, 143 cases 89. 9% ) were cured, the neurological symptoms were apparently improved in 8 cases ( 5% ) , and unchanged in 5 cases 3. 1% ) . Three cases recurred. One case was operated on again. No operative death occurred. [ Conclusion ] Early diagnosis and treatment of spinal tumor are important measures to improve prognosis. Detailed history - taking, careful examination and MRI imaging play a key role in the diagnosis and treatment of spinal tumors.