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中文摘要：
[目的]探讨纳米铁粉对小鼠血糖、血脂的影响。[方法]分别以5g／kg剂量碱米粒径铁扮（Micro—Fe）或纳米粒径铁粉（Nano—Fe）给小鼠1次经口灌胃．14d后处死;测定肝、肾脏器系数、血糖（Glu）、总胆固醇（TC）、甘油三醇（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL—C）的变化。[结果]Micro—Fe和Nano-Fe染毒小鼠肝脏系数明显高于对照组相（P〈0．05）。与对照组相比，Nano-Fe染毒小鼠血清Glu明显降低（P〈0．05）；Micro—Fe组血清TG比control组有明显升高（P〈0.05）．Nano—Fe组血清TG比control组有升高趋势．但差异无统计学意义（P〉0．05）。Control、Micro—Fe和Nano—Fe杀毒组3组小鼠血清代、LDL-C和HDL-C水平间差异无统计学意义（P〉0.05）。[结论]大剂量Nano-Fe经口染毒可使血清Glu降低．对TC、TG、HDL-C和LDL-C无明显影响。
英文摘要：
[Objective] To explore the effect of nano-partieles iron on serum glucose and lipids in mice. [Methods] The raises were treated with the oral exposure dose in 5 g/kg of microor hans-size iron powder and executed 14 days later to be detected correlative serum biochemical indicators. [Results] The live/bedy eoeffeient of micro-and nano -size iron powder group were obviously higher than that of control group, The serum glucose of nano-size Iron powder group was lower than that of eontml group and micro-size Iron powder group sigrtificandy （P 〈 0.05） . The serum TG el micro-particles Iron group was obvionsly higher than that of control, though the TG of nano-parLicles Iron group was also higher than that of contol, there was no obvious difference between them （P 〉 0.05） . There were no any differences in serum TC, HDL-C and LDL-C among the control, micro- and hans-size iron group. [Conclusions] Large dose of the hans-size iron powder has greater effect on serum glucose but without any different effects on serum TG, TC, HLD-C and LDL-C compared with the ordinary iron material.
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