一个多功能的、双药的搬运人平台成功地被构造。核心壳组织了 NaGdF 4:Yb/Er@NaGdF4:Yb@mSiO2-polyethylene 乙二醇(作为 UCNPS 缩短了) 与 antitumor 药装载的 nanoparticles, doxorubicin (纪录影片) 被合并到 poly (-caprolactone)( 打印机控制语言) 和明胶与消炎的药装载了,消炎痛(MC ) 到形式 nanofibrous 织物(作为 MC/UCNPS/DOX 标记) 经由 electrospinning 过程。结果的多功能的旋转片能通过手术作为 orthotopic 化疗在老鼠的肿瘤地点直接被植入由从 mesoporous 硅二氧化物的控制版本纪录影片(通过 NaGdF 4:Yb/Er@NaGdF4:Yb 的双模型的成像在 vivo 在 MC/UCNPS/DOX 嵌入的 SiO 2) 和 upconversion fluorescence/magnetic 回声。
A multifunctional, dual-drug carrier platform was successfully constructed. Core-sheU structured NaGdF4:Yb/Er@NaGdF4:Yb@mSiO2-polyethylene glycol (abbreviated as UCNPS) nanopartides loaded with the antiturnor drug, doxorubicin (DOX) were incorporated into poly(~-caprolactone) (PCL) and gelatin loaded with antiphlogistic drug, indomethacin (MC) to form nanofibrous fabrics (labeled as MC/UCNPS/DOX) via electrospinning process. The resultant multifunctional spinning pieces can be surgically implanted directly at the tumor site of mice as an orthotopic chemotherapy by controlled-release DOX from mesoporous silicon dioxide (SiO2) and upconversion fluorescence/magnetic resonance dual-model imaging through NaGdF4:Yb/Er@NaGdF4:Yb embedded in MCfldCNPS/DOX invivo.