中文摘要：

目的利用1H-NMR为基础的代谢组学研究牛黄解毒片中人工牛黄、石膏、冰片3味中药对雄黄的配伍减毒作用。方法42只大鼠随机分成6组：A组（对照组）、B组（雄黄组）、C组（牛黄解毒片组）、D组（牛黄解毒片去人工牛黄组）、E组（牛黄解毒片去石膏组）、F组（牛黄解毒片去冰片组）。对各组大鼠尿液及血清样品1H—NMR谱图进行模式识别分析。结果雄黄组大鼠样品代谢轮廓和对照组差异明显，其他各组大鼠代谢轮廓同对照组相似，向对照组回归。结论牛黄解毒片中人工牛黄、石膏、冰片3味中药对雄黄配伍减毒作用不明显。

英文摘要：

Objective To study the toxicity alleviation effect of Bovis Calculus Arttficialis, Gypsum Fibrosum, and Borneolum Synthcticum to Realgar in Niuhuang Jiedu Tablet based on tH-NMR metabonomics, Methods Forty-two male Wistar rats were divided into six groups： group A （control group）, group B （treated with realgar）, group C （treated with Niuhuang Jiedu Tablet）, group D （treated with Niuhuang Jiedu Tablet without Bovis Calculus Artificialis）, group E （treated with Niuhuang Jiedu Tablet without Gypsum Fibrosum）, and group F （treated with Niuhuang Jiedu Tablet without Borneolum Synthcticum）. Based on 1H-NMR spectra of urine and serum from rats, PLS-DAwas performed to identify different metabolic profiles. Results The metabolic profiles of group B were different from control group, while the metabolic profiles of all other groups were almost in line with those of control group. Conclusion The toxicity alleviation effects of Bovis Calculus Arttficialis, Gypsum Fibrosum, and Borneolum Synthcticum to Realgar in Niuhuang Jiedu Tablet are not obvious.