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Environmental RNA interference in animals
  • 期刊名称:Chinese Science Bulletin 2013
  • 时间:2013
  • 页码:4418-4425
  • 分类:Q522[生物学—生物化学] S937[农业科学—渔业资源;农业科学—水产科学]
  • 作者机构:[1]School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China, [2]School ofLife Sciences & Key Laboratory of Brain Function and Disease of Chinese Academy of Sciences, University of Science and Technology of China Hefei 230027, China
  • 相关基金:The authors thank the members of the Ge Shan lab for discussion. This work was supported by the National Basic Research Program of China (2011CBAOll03), National Natural Science Foundation of China (81171074, 91232702, and 31071132), and the Knowledge Innovation Project of CAS (1731112304041) to G. Shan.
  • 相关项目:OxyS非编码RNA对秀丽线虫che-2基因表达与行为的调控
中文摘要:

动物总是与他们的环境交往,并且必须反应到在环境在场的各种因素。环境 RNA 干扰指外长的 RNA 分子能进入的现象某些动物种的细胞并且防碍这些动物的基因表示。这些外长的 RNA 可以是在动物食物的分子,或可能在从另外的来源的生活环境在场。为为他们在基因干扰的功能的环境 RNA 并且进一步的房间入口的分子的小径开始在动物模型 Caenorhabditis elegans 被揭示了。这里,我们在动物加亮环境 RNA 干扰(RNAi ) 的一些已知的例子并且在下面介绍分子的机制。

英文摘要:

Animals interact with their environments all the time, and must react to all kinds of factors present in the environments. Environmen- tal RNA interference refers to the phenomenon that exogenous RNA molecules can enter cells of certain animal species and inter- fere with gene expression of these animals. These exogenous RNAs may be molecules in animal food, or may be present in the living environment from other sources. Molecular pathways for the cell entry of environmental RNAs and further for their func- tionality in gene interference have started to be revealed in the animal model Caenorhabditis elegans. Here we highlight some known examples of environmental RNA interference (RNAi) in animals and introduce the molecular mechanisms underneath.

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