中文摘要：

本研究旨在探明胰岛素样生长因子结合蛋白（insulin-like growth factor-binding protein,IGFBP）在内蒙古白绒山羊绒毛发育的不同生长阶段皮肤组织中的表达变化情况。试验采用实时荧光定量PCR技术,对内蒙古白绒山羊绒毛生长发育的各个时期皮肤中IGFBP-1～IGFBP-6基因的表达进行了测定,并通过埋植褪黑素组改变绒毛生长周期的研究,来鉴定IGFBP-1～IGFBP-6基因中高表达的结合蛋白的作用。结果表明,IGFBP-3和IGFBP-5在绒山羊绒毛生长发育的各个时期的皮肤组织中均有表达,但是IGFBP-5的表达相对于IGFBP-3的表达具有很强的规律性。结果提示,在内蒙古白绒山羊的绒毛发育过程中,IGFBP-5可能是一个主要的调控因子。

英文摘要：

This experiment was conducted to study the expression effect of insulin-like growth factor-binding protein（IGFBP）of Inner Mongolia Cashmere goat skin in different developmental stage.The expression of IGFBP-1 to IGFBP-6 in different developmental stage of hair follicle cycle was measured by Real-time PCR.Furthermore,the hair growth cycle was changed by implanting melatonin to identify the role of IGFBP-1 to IGFBP-6 gene,the high expression of the binding protein.The results showed that IGFBP-3 and IGFBP-5 both were expressed in different developmental stage of hair follicle cycle,however,the expression of IGFBP-5 gene presented more regular.The results indicated that IGFBP-5 might be a major regulatory factor in the process of hair follicle development of Inner Mongolia Cashmere goat.