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Multiple hemodynamic effects of endogenous hydrogen sulfide on central nervous system in rats

ISSN号：0366-6999
期刊名称：Chinese Medical Journal
时间：0
页码：3468-3475
分类：Q754[生物学—分子生物学] TE644[石油与天然气工程—油气加工工程]
作者机构：[1]Department of Cardiac Center, Peking University People＇s Hospital, Beijing 100044, China
相关基金：This work was supported by grants from the Major State Basic Research Development Program of China （No. 2006CB503807） and the National Natural Science Foundation of China （No. 30971084, 30821001）.
相关项目：代谢性核受体在糖脂代谢调控中的作用机制

关键词：原发性高血压, 硫化氢, 红细胞, 血清, 治疗, 协会, 硫化物, 高密度脂蛋白胆固醇, erythroeyte, hydrogen sulfide, 3-mercaptopyruvate sulphurtransferase, hypertension

中文摘要：

在这研究的 hypertension.The 目的一个重要角色是与未经治疗的必要 hypertension.Methods 在病人调查红血球和浆液 H2S 的角色的背景内长的氢硫化物( H2S )戏我们与未经治疗的 prehypertension 或高血压招募了 62 个病人(年龄 22-74 年)，并且 .We 估计了的 64 个正常血压的题目(年龄 18-64 年)在红血球的 3-mercaptopyruvate sulphurtransferase ( MPST )蛋白质表示并且从红血球和 se 测量了 H2S 生产

英文摘要：

Background Endogenous hydrogen sulfide （H2S） plays an important role in hypertension. The aim of this study was to investigate the role of erythrocyte and serum H2S in patients with untreated essential hypertension. Methods We recruited 62 patients （age 22-74 years） with untreated prehypertension or hypertension, and 64 normotensive subjects （age 18-64 years）. We assessed the 3-mercaptopyruvate sulphurtransferase （MPST） protein expression in erythrocytes and measured the H2S production from erythrocytes and serum H2S levels, then analyzed the association of erythrocytic or serum H2S content and blood pressure or cardiovascular risk factors （e.g., age, body mass index （BMI） and dyslipidemia）. A stepwise regression analysis was used to evaluate the possible relationship of erythrocytic H2S in hypertension. Results In hypertensive patients, erythrocyte H2S production （（111.04_＋.29.20） nmol/min per 10a erythrocytes） was higher than that in controls （（78.85＋19.38） nmol/min per 108 erythrocytes）, and serum H2S was also higher. The erythrocytic H2S production was associated with increased systolic blood pressure （sBP）, diastolic blood pressure （dBP）, age, BMI, level of C-reactive protein （CRP）, as well as triglycerides （TG） and high density lipoprotein cholesterol （HDL-C） Serum H2S was not associated with age or CRP. Stepwise regression analysis showed that erythrocytic H2S production was correlated with sBP, TG, HDL-C, low density lipoprotein cholesterol （LDL-C） and blood urea nitrogen （BUN） and serum H2S was correlated with dBP and TG. Results of receiver-operating characteristic curve analysis suggested that erythrocytic H2S production was a more sensitive predictor of hypertension development than serum H2S. Conclusion Ervthrocvtic or serum H~S Production is sensitive predictor of hvDertension.