中文摘要：

目的验证非甾体类抗炎药物盐酸苄达明对急性高原病的预防效果。方法将急进5 200 m高原的118例健康青年官兵随机分为安慰剂组（n=20）、复方红景天组（n=33）、复方党参组（n=33）、盐酸苄达明组（n=33）,自海拔1 400 m,历时5 d进入5 200 m高原。从出发前5 d开始分别服用盐酸苄达明片、复方红景天胶囊、复方党参胶囊和安慰剂胶囊,定期测试其血氧饱和度（SaO2）和心率（HR）,并以军用卫生标准GJB1098-91《急性高原反应的诊断和处理原则》随访记录受试者急性高原反应症状,然后分度评分;进入高原后第7天进行高原习服基础生理指标测定,进行药效评价。结果盐酸苄达明对全程试验期内受试者高原缺氧所致头痛和呕吐的预防效果显著优于安慰剂,且对头痛症状的预防效果优于复方红景天与复方党参。盐酸苄达明组受试者急性高原反应GJB评分,进入海拔5 200 m高原第3、5天SaO2、心率,高原习服基础生理指标等均显著优于安慰剂组。结论非甾体类抗炎药物盐酸苄达明防治急性高原病效果显著。

英文摘要：

Objective To test and verify the effects of benzyamine hydrochloride,a non-steroid anti-inflammatory drug,to prevent acute mountain sickness.Methods Totally 118 cases of healthy young soldiers were randomly divided into four groups respectively treated by placebo（n=20）,compound rhodiola（n=33）,compound codonopsis capsules（n=33）,benzyamine hydrochloride（n=33） starting 5 days before departure and quickly approached into the altitude 5 200 m from 1 400 m in 5 days.Blood oxygen saturation（SaO2） and heart rate（HR） were regularly tested and acute mountain sickness symptoms of subjects were follow-up recorded and scored according to the military standard GJB1098-91;Basic high altitude acclimatization physiological parameters were determined and evaluated from seventh day after reaching the plateau.Results The effect of benzyamine hydrochloride to prevent headache and vomiting due to high altitude was significantly superior to placebo during the trial period,and the effect of prevention of headache was also better than compound codonopsisand compound rhodiola.GJB score of benzyamine hydrochloride in acute mountain sickness,SaO2,HR and basic high altitude acclimatization physiological parameters were significantly superior to placebo in the third and fifth day at the altitude 5 200 m.Conclusion The effect of benzyamine hydrochloride to prevent acute mountain sickness is remarkable.