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关于茎点霉联烯酸丙的绝对构型
  • ISSN号：0567-7351
  • 期刊名称：《化学学报》
  • 时间：0
  • 分类：O626.11[理学—有机化学;理学—化学] TQ225.1[化学工程—有机化工]
  • 作者机构：[1]中国科学院上海有机化学研究所生命有机化学国家重点实验室,上海200032
  • 相关基金：国家自然科学基金（Nos.20372075,20321202,20672129,20621062,20772143）;中国科学院[知识创新工程,（KJCX2.YW.H08）]资助项目.
作者： 简亚军[1], 张艳[1], 伍贻康[1]
关键词： Mosher酯, 对映体, 丙炔醇, 不对称还原, 联烯, Mosher ester, enantiomer, propargylic alcohol, asymmetric reduction, allene
中文摘要：

茎点霉联烯酸丙1是一具全新作用机制的天然抗菌化合物，其绝对构型在全合成中是从关键中间体炔丙醇4的绝对构型来推定的．由于后者本身依赖于经验规则，进一步获取实验证据显得很有必要．为此我们用Mosher酯法对炔丙醇4的绝对构型进行了测定．结果表明原先推定的绝对构型是正确的．

英文摘要：

The absolute configuration of phomallenic acid C （1）, a recently isolated natural antibiotic with a novel mode of action, was previously established in a total synthesis through deduction from the configuration of a key intermediate 4 assigned on an empirical basis. Further experimental evidence is therefore highly desirable. In the present work the absolute configuration of the key propargylic alcohol 4 was determined using the method developed by Mosher. The results show that the previously assigned absolute configuration of I is correct.

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期刊信息
  • 《化学学报》
  • 北大核心期刊（2014版）
  • 主管单位:中国科学院
  • 主办单位:中国化学会 中国科学院上海有机化学研究所
  • 主编：周其林
  • 地址：上海市零陵路345号
  • 邮编：200032
  • 邮箱：hxxb@sioc.ac.cn
  • 电话：021-54925085
  • 国际标准刊号：ISSN：0567-7351
  • 国内统一刊号：ISSN：31-1320/O6
  • 邮发代号:4-209
  • 获奖情况:
  • 首届国家期刊奖,第二届国家期刊奖提名奖,中国期刊方阵“双高期刊”
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,英国英国皇家化学学会文摘,中国北大核心期刊（2000版）
  • 被引量:28694