中文摘要：

目的：观察吡哆醇诱导的大鼠感觉神经元病模型的特点，为该病的治疗提供可靠的动物模型实验数据。方法：成年雌性SD大鼠，采用早、晚2次，腹腔内注射800mg·kg^-1·d^-1吡哆醇，持续8d，制作感觉神经元病动物模型。通过对比大鼠行为学、神经电生理学、组织形态学观察及计量等实验方法，对模型鼠进行综合评价。结果：吡哆醇造模后，动物步态蹒跚，其身体平衡及稳定性变差；足底的温度觉和痛觉敏感度显著降低；坐骨神经感觉潜伏期延长，传导速度降低；背根神经节的神经元萎缩、变性伴有坏死，坐骨神经发生轴索变性，伴有髓鞘塌陷、扭曲；腓肠肌湿重显著降低。结论：通过腹腔注射过量吡哆醇的方法制作的动物模型符合预期的感觉神经元病的病理学特征。

英文摘要：

Objective： To observe the characteristics of the sensory neuron disease model of rats induced by pyridoxine and to provide reliable test data for the treatment of the disease. Methods： The adult female SD rats were intraperitoneally injected twice in the morning and evening per day with 800 mg·kg^-1·d^-1 pyridoxine hydrochloride for 8 days. The model rats were evaluated by comparing their behaviors, nerve electrophysiology, and tissue morphology. Results： The body equilibrium and stability of the animal varied after the model was made by intraperitoneal injection of pyridoxine. The temperature of the plantar sensation and pain sensitivity reduced significantly. The sensory latency of the sciatic nerve was prolonged and the conduction velocity was reduced. The neurons of the dorsal root ganglion were atrophic, degenerative and necrotic with the axonal degeneration of the sciatic nerve accompanied by the subsidence and distortion of the myelin sheath. Tl-e wet weight of gastrocnemius muscle reduced significantly. Conclusion： The animal model made by intraperitoneal injection of pyridoxine is in line with the pathological features of sensory neuron disease.