中文摘要：

以双甲基丙烯酰-β-环糊精（BMA-β-CD）和2-（二乙基胺基）乙基甲基丙烯酸酯（DEAEM）为功能单体制备了胆酸印迹聚合物MIP1,并采用平衡结合实验研究了MIP1在含水介质中对模板分子的识别能力.结果表明,MIP1比单独以BMA-β-CD或DEAEM为功能单体制备的印迹聚合物MIP2和MIP3显示出对模板分子更好的选择性结合能力.MIP1的特异性吸附量（ΔcP）为38.81μmol/g,印迹因子IF为2.46.研究结果表明,在含水介质中,利用模板分子与功能单体之间的疏水作用和离子作用是提高印迹聚合物分子识别能力的关键.另外,在识别过程中,疏水作用在驱动分子进入印迹孔穴时起重要作用.

英文摘要：

In order to achieve effective imprinting in aqueous media,a cholic acid imprinted polymer（MIP1） was prepared using bismethacryloyl-β-cyclodextrin（BMA-β-CD） and 2-（diethylamino） ethylmethacrylate（DEAEM） as functional monomers.The recognition ability of MIP1 for the template in aqueous media was evaluated by equilibrium binding experiments.The results indicated that the imprinted polymer MIP1 obviously exhibited a higher selectivity for cholic acid than the cholic acid imprinted polymers（MIP2 and MIP3） using only BMA-β-CD or DEAEM as functional monomer.The specific binding capacity（ΔcP） and imprinting factor（IF） of MIP1 were 38.81 μmol/g and 2.46,respectively.It was demonstrated that the combination of hydrophobic effect and electrostatic interaction in molecular imprinting was essential for the improvement of selective ability of the imprinted polymer in aqueous media.In addition,hydrophobic effect was confirmed to be an important force for driving the template molecules into the cavities created by the imprinting process.