中文摘要：

目的：从脑内铁代谢的角度研究铁在外伤后癫痫（PTE）发病机制中的可能作用。方法：用ELISA方法检测PTE大鼠模型脑组织内铁蛋白（Ft）和转铁蛋白（Tf）的动态含量。结果：早期Ft在整个脑组织内呈现为即刻反应性升高，15d后其含量在实验对侧脑组织内恢复至正常范围，而在实验侧脑组织内呈现继续升高的趋势；Tf含量只在实验侧脑组织内升高，且呈现随时间继续升高趋势。结论：PTE大鼠模型中的铁代谢过程十分复杂。相关蛋白尤其是Tf含量的增加提示铁可能是外伤后癫痫灶形成机制的一部分。

英文摘要：

Aim： To study the change of iron metabolism in the brain of the post traumatic epilepsy （PTE） animal model, identify the role of the iron in the mechanism of the PTE. Methods： The method introduced by Willmore to establish rat model of PTE, detected the content of the ferritin （Ft） and transferring （Tf） in the brain tissue by enzyme-linked immunosorbentassay （ELISA）. Results： The content of the Ft was increased instantly in the whole brain tissue in the early time, 15 days later, its content in the opposite side brain tissue was decreased, but the content in the experimental side brain tissue presented a tendency of increase. The content of the Tf raised to a high level only in the experimental side brain tissue and had a tendency of increase with the development of time. Conclusion： Iron metabolism in the brain of PTE animal model is very complex, the growth of the correlating proteinsi contents, especially Tf, prompts that iron may be a part of the mechanism of PTE.