目的:观察银杏叶提取物联合醋酸泼尼松对上呼吸道感染后嗅觉障碍(PVOD)患者的临床治疗效果。方法:将42例明确上呼吸道感染后出现嗅觉障碍,同时排除鼻腔阻塞因素的患者随机分为两组,分别给予醋酸泼尼松和醋酸泼尼松联合银杏叶提取物治疗,在治疗前及治疗后1~3个月分别行T&T嗅觉测试和Sniffin Sticks嗅觉测试,将治疗前后嗅觉功能测试结果进行统计分析。结果:20例PVOD患者经过醋酸泼尼松治疗,T8乙T嗅觉测试结果显示5例(25.00%)患者嗅觉功能恢复正常,9例(45.00%)改善;Sniffin Sticks嗅觉测试结果显示4例(20.00%)患者嗅觉功能恢复正常,10例(50.00%)改善。22例PVOD患者加用银杏叶提取物治疗,T&T嗅觉测试结果显示7例(31.82%)患者嗅觉功能恢复正常,11例(50.00%)改善;Sniffin Sticks嗅觉测试结果显示6例(27.27%)患者嗅觉功能恢复正常,12例(54.55%)改善。结论:醋酸泼尼松和醋酸泼尼松联合银杏叶提取物对PVOD有治疗效果。两种方案的治疗效果虽在统计学上无明显差异,但联合银杏叶提取物的治疗效果有好于单独使用醋酸泼尼松的趋势。治疗时间延长有助于嗅觉功能的恢复。
Objective:To observe the effect of ginkgo biloba extraction combined with glucocorticoids on post- viral olfactory dysfunction. Method:Forty-two patients were diagnosed as postviral olfactory dysfunction. All pa- tients underwent olfactory test, including T&T test and Sniffin Sticks test before and after treatment. The treat- ment lasted up to 3 months based on effectiveness. The results of olfactory test were recorded every month. Re- suit.. Twenty patients received the treatment with prednisone acetate. T~T test showed that the effective and im- provement rate of the treatment with prednisone acetate were 25.00% (5/20) and 45.00% (9/20), respectively; Sniffin Sticks test showed that the effective and improvement rate of the treatment were 20.00% (4/20) and 50.00% (10/20), respectively. Twenty-two patients received the treatment combined with extract of ginkgo bi- loba. T&T test showed that the effective and improvement rate of the treatment with prednisone acetate were 31.82% (7/22) and 50.00% (11/22), respectively; through Sniffin Sticks test showed that the effective and im- provement rate of the treatment were 27.27 % (6/22) and 54.55 % (12/22), respectively. Conclusion: Olfactory function in patients with postviral olfactory dysfunction was improved with two therapy. There was no significant difference on effect between the two therapeutic groups, was better than the effect of prednisone acetate. Prolong tion. but the effect of combination of extract of ginkgo biloba duration of treatment is help for the recovery of the olfac-tion.