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糖皮质激素及银杏叶提取物治疗上呼吸道感染后嗅觉障碍临床效果观察
  • ISSN号:1001-1781
  • 期刊名称:《临床耳鼻咽喉头颈外科杂志》
  • 时间:0
  • 分类:R765.6[医药卫生—耳鼻咽喉科;医药卫生—临床医学]
  • 作者机构:首都医科大学附属北京安贞医院耳鼻咽喉头颈外科,北京100029
  • 相关基金:国家自然基金项目(No:81670903)
中文摘要:

目的:观察银杏叶提取物联合醋酸泼尼松对上呼吸道感染后嗅觉障碍(PVOD)患者的临床治疗效果。方法:将42例明确上呼吸道感染后出现嗅觉障碍,同时排除鼻腔阻塞因素的患者随机分为两组,分别给予醋酸泼尼松和醋酸泼尼松联合银杏叶提取物治疗,在治疗前及治疗后1~3个月分别行T&T嗅觉测试和Sniffin Sticks嗅觉测试,将治疗前后嗅觉功能测试结果进行统计分析。结果:20例PVOD患者经过醋酸泼尼松治疗,T8乙T嗅觉测试结果显示5例(25.00%)患者嗅觉功能恢复正常,9例(45.00%)改善;Sniffin Sticks嗅觉测试结果显示4例(20.00%)患者嗅觉功能恢复正常,10例(50.00%)改善。22例PVOD患者加用银杏叶提取物治疗,T&T嗅觉测试结果显示7例(31.82%)患者嗅觉功能恢复正常,11例(50.00%)改善;Sniffin Sticks嗅觉测试结果显示6例(27.27%)患者嗅觉功能恢复正常,12例(54.55%)改善。结论:醋酸泼尼松和醋酸泼尼松联合银杏叶提取物对PVOD有治疗效果。两种方案的治疗效果虽在统计学上无明显差异,但联合银杏叶提取物的治疗效果有好于单独使用醋酸泼尼松的趋势。治疗时间延长有助于嗅觉功能的恢复。

英文摘要:

Objective:To observe the effect of ginkgo biloba extraction combined with glucocorticoids on post- viral olfactory dysfunction. Method:Forty-two patients were diagnosed as postviral olfactory dysfunction. All pa- tients underwent olfactory test, including T&T test and Sniffin Sticks test before and after treatment. The treat- ment lasted up to 3 months based on effectiveness. The results of olfactory test were recorded every month. Re- suit.. Twenty patients received the treatment with prednisone acetate. T~T test showed that the effective and im- provement rate of the treatment with prednisone acetate were 25.00% (5/20) and 45.00% (9/20), respectively; Sniffin Sticks test showed that the effective and improvement rate of the treatment were 20.00% (4/20) and 50.00% (10/20), respectively. Twenty-two patients received the treatment combined with extract of ginkgo bi- loba. T&T test showed that the effective and improvement rate of the treatment with prednisone acetate were 31.82% (7/22) and 50.00% (11/22), respectively; through Sniffin Sticks test showed that the effective and im- provement rate of the treatment were 27.27 % (6/22) and 54.55 % (12/22), respectively. Conclusion: Olfactory function in patients with postviral olfactory dysfunction was improved with two therapy. There was no significant difference on effect between the two therapeutic groups, was better than the effect of prednisone acetate. Prolong tion. but the effect of combination of extract of ginkgo biloba duration of treatment is help for the recovery of the olfac-tion.

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期刊信息
  • 《临床耳鼻咽喉头颈外科杂志》
  • 北大核心期刊(2011版)
  • 主管单位:中华人民共和国教育部
  • 主办单位:华中科技大学同济医学院附属协和医院
  • 主编:黄选兆 孔维佳
  • 地址:武汉解放大道1277号
  • 邮编:430022
  • 邮箱:lcebh@yahoo.com.cn
  • 电话:027-85726342-8818
  • 国际标准刊号:ISSN:1001-1781
  • 国内统一刊号:ISSN:42-1764/R
  • 邮发代号:38-146
  • 获奖情况:
  • 全国优秀科技期刊,中国科技论文统计源期刊,中文核心期刊,中国期刊方阵“双效”期刊
  • 国内外数据库收录:
  • 美国化学文摘(网络版),荷兰文摘与引文数据库,美国生物医学检索系统,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版)
  • 被引量:12291