秀丽隐杆线虫具有受机械接触、温度、化学物质、离子、外激素等多种环境刺激产生敏感反应的能力,其已被证明是研究行为可塑性的理想模式生物。文章阐述了秀丽隐杆线虫非联合型学习和联合型学习的研究方法、研究模型和相关分子遗传机制,为了解高等动物学习过程、机理及相关疾病研究提供了重要信息。
The nematode Caenorhabditis elegans is an attractive model organism for studying the behavioral plasticity because of its ability to respond to diverse environmental stimuli such as touch, temperature,chemical,and pheromone. C elegans have learning ability including both non-associative learning and associative learning. This review discusses the methods, models, molecular and genetic mechanisms of these two kinds of learning behaviors in Caenorhabditis elegans,which will provide a crucial novel imformation for understanding the process,mechanism and disease related to learning.