目的:探讨经皮冠状动脉支架植入术前中性粒细胞/淋巴细胞比值(Neutrophil-to-LymphocyteRatio,NLR)与患者药物支架(DrugElutingStent,DES)植入后发生支架内再狭窄(In—StentRestenosis,ISR)的关系。方法:回顾性分析2012年01月至2012年10月间有DES植入史并再次入院接受冠脉造影的92例患者(平均年龄65.22±9.73岁)的血液学检查、既往冠脉造影结果及再次冠脉造影结果。根据DES植入前的NLR的四分位点将所有入选患者分为3组:最低三分位组(n=31,0.91-1.83),中间三分位(n=30,1.87—2.63),最高三分位(n=31,2.66—4.67),比较3组间ISR发生率有无差异。结果:再狭窄发生在最低NLR三分位的有3例(9.68%),发生在中间NLR三分位组的有2例(6.67%),而有4例(12.90%)发生在NLR最高三分位组(P=0.714),3组之间的差异无统计学意义。结论:因稳定或不稳定型心绞痛而植入药物支架的患者,其术前NLR同支架术后ISR的发生无明显相关性。NLR不能作为DES植入后发生再狭窄的预测指标。
Objective: The aim of the present study was to investigate the predictive value ofpreprocedural Neutrophil-to-Lymp- hocyte Ratio (NLR) on development of In-Stent Restenosis (ISR) in patients undergoing coronary drug eluting stent (DES) implantation. Methods: We retrospectively analyzed clinically hematologic and angiographic data of 92 patients (mean age 65.22±9.73 years, 73% men, 27% women) who had undergone successful DES implantation because of stable or unstable angina pectoris and a further control coronary angiography owing to follow-up or stable or unstable angina pectoris. Patients were divided into 3 tertiles based on preprocedural NLR. Results: Restenosis occurred in 3 patients (9.68%) in the lowest tertile, in 2 patients (6.67%)in the middle tertile, and in 4 patients (12.90%) in the highest NLR tertile (P=0.714). Conclusions: The preprocedural NLR of patients who had undergone successful drug-eluting stent implantation because of stable or unstable angina pectoris is not correlated with ISR. The NLR could not be a predictor for restenosis after DES implantation.