象乙烯肼 tetraacetic 酸(H4edta ) 那样的在结构上不同的羧基的酸的集中的效果,柠檬性的酸(H3cit ) ,酒石的酸(H2tart ) ,和在胶化系统的钙盐(CaOxa ) 的生长和聚集上的醋酸(HOAc ) 比较地被调查。H2tart 和 H3cit 能改变钙盐一水化物(COM ) 的形态学并且导致钙盐二水合物(货到付款) 的形成。H4edta 能在 0.33 mmol/L 的更低的集中导致货到付款的形成并且有最强壮的能力禁止 COM 的聚集。HOAc 比 500 mmol/L 仅仅在更高的集中禁止了 COM 聚集。与在酸增加羧基的组的数字或增加羧基的酸的集中,这酸的能力增加了导致货到付款形成并且禁止 COM 晶体的生长和聚集。也就是说,这个能力跟随了顺序: H4edta > H3cit > H2tart >> HOAc。在这个工作的结果建议在尿的 H3cit 和 H2tart 的存在对石头形成在自然防卫起了一个作用。
The effect of concentration of structurally-different carboxylic acids such as ethylene diamine tetraacetic acid (H4edta), citric acid (H3cit), tartaric acid (H2tart), and acetic acid (HOAc) on growth and aggregation of calcium oxalate (CaOxa) in gel systems was comparatively investigated. H2tart and H3cit could change the morphology of cal- cium oxalate monohydrate (COM) and induce the formation of calcium oxalate dihydrate (COD). H4edta could induce the formation of COD at a lower concentration of 0.33 mmol/L and have the strongest ability to inhibit aggregation of COM. HOAc inhibited COM aggregation only at a higher concentration than 500 mmol/L. With increasing the number of carboxylic groups in an acid or increasing the concentration of carboxylic acid, the capacity of this acid to induce COD formation and to inhibit growth and aggregation of COM crystals increased. That is, this capacity followed the order: H4edta〉H3cit〉H2tart〉 〉HOAc. The result in this work suggested that the presence of H3cit and H2tart in urine played a role in the natural defense against stone formation.