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王道坤运用枳实消痞汤辨治老年慢性萎缩性胃炎经验介绍
  • ISSN号:0256-7415
  • 期刊名称:《新中医》
  • 时间:0
  • 分类:S668.1[农业科学—果树学;农业科学—园艺学] S858.232.5[农业科学—临床兽医学;农业科学—兽医学;农业科学—畜牧兽医]
  • 作者机构:[1]Institute of Integrated Chinese and Western Medicine, School of Basic Medical Sciences, Lanzhou University, Gansu 730020, China, Department of Basic Courses, Gansu College of Traditional Chinese Medicine, Lanzhou 730020, China, [2]Institute of Integrated Chinese and Western Medicine, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730020, China, [3]Department of Basic Courses, Gansu College of Traditional Chinese Medicine, Lanzhou 730020, China
  • 相关基金:Supported by National Natural Science Fund (No.81260519); Science and Technique Plan of the Administration of Traditional Chinese Medicine of Gansu Province(No.07-GZK-07); Experimental Plan for Young and Middleaged Teacher of Gansu College of Traditional Chinese Medicine(No. 05ZQ-03/09ZQ-09)
中文摘要:

在乳的脱氢酶(LDH ) 上学习 Zhiwei Fangbian 囊(ZWFBC ) 的效果的目的,琥珀酸脱氢酶(同步数字系列) 和在长期的衰退胃炎(CAG ) 的胃的 mucosa 的 ATPase 活动有 Qi 的老鼠缺乏和血壅滞症候群。完全, 90 只老鼠随机被划分成 2 个组的方法:正常的组(n=10 ) 和模型组(n=80 ) 。Qi 缺乏和血壅滞类型的 CAG 老鼠模特儿被合成方法劝诱。在当模特儿 12 个星期和成功的 CAG 模型是坚定的以后, CAG 模型老鼠在随机的数字桌子边被划分成模型组( MG ), ZWFB 高剂量的组( ZWFBH ), ZWFB 中间剂量的组( ZWFBM ), ZWFB 低剂量的组( ZWFBL )和 Weimeisu 组( WM ),在每个组的 9 只老鼠。在正常和模型组的老鼠 intragastrically 与提取的水被管理, 10 mL/kg 每天;有 ZWFB 的 ZWFB 高剂量的组, 0.6 g 散汬?湩?噉???慰楴湥獴?湡?潴攠灸潬敲琠敨甠摮牥祬湩?敭档湡獩?景琠楨?桴牥灡??敍桴摯?倊慬浳?档湡敧?湩???????????????????????剄?????????湡???????剄?敬敶獬椠????卄瀠瑡敩瑮?牴慥整?楷桴?做?映牯猠硩洠湯桴?敷敲攠慸業敮?祢映潬?祣潴敭牴?湡?潣灭牡摥眠瑩?敬敶獬椠?敨污桴?潣瑮潲獬?刊獥汵獴?桔?汣湩捩污琠楲污椠据畬敤??漠瑵慰楴湥獴眠瑩????卄?敂潦敲琠敲瑡敭瑮?汰獡慭氠癥汥?景???愠摮????漠?????散汬?敷敲栠杩敨?桴湡琠潨敳椠??栠慥瑬?潣瑮潲獬?????吠敨敲眠牥?潮猠杩楮楦慣瑮挠慨杮獥椠?敳畲?敬

英文摘要:

OBJECTIVE: To study the effects of Zhiweifangbian (ZWFB) capsule on lactic dehydrogenase (LDH), succinic dehydrogenase (SDH) and ATPase activities in gastric mucosa of chronic atrophic gastritis (CAG) rats with Qi deficiency and blood stasis syndrome. METHODS: Totally 90 rats were randomly divided into 2 groups: normal group (n=10) and modelgroup (n=80). The CAG rat model of Qi deficiency and blood stasis type was induced by synthetic methods. After modeling for 12 weeks and the successful CAG model was determined, the CAG model rats were divided by random number table into model group (MG), ZWFB high-dose group (ZWFBH), ZWFB middle-dose group (ZWFBM), ZWFB low-dose group (ZWFBL) and Weimeisu group (WM), 9 rats in each group. The rats in the normal and model groups were intragastrically administrated with distilled water, 10 mL/kg every day; the ZWFB high-dose group with ZWFB, 0.6 g/ kg -1 · d -1 ; the ZWFB middle-dose group with ZWFB, 0.3 g/kg -1 · d -1 ; the ZWFB low-dose group with ZWFB, 0.15 g/kg -1 · d -1 , and the WM group with suspension of WM , 0.25 g/kg -1 · d -1 . The treatment was given for 90 consecutive days. Then general survival states were observed and the activities of LDH, SDH, Na + -K + -ATPase and Ca 2+ -Mg 2+ -ATPase in gastric mucosa tissue were detected. RESULTS: Compared with the normal group, activity of LDH in the gastric mucosa (P〈0.05) and activities of SDH, Na + -K + -ATPase and Ca 2+ -Mg 2+ -ATPase significantly decreased in the normal group (P〈0.05). Compared with the model group the activity of LDH decreased and activities of SDH, Na + -K + -ATPase and Ca 2+ -Mg 2+ -ATPase significantly increased in the high dose ZWFB group (P〈0.05). CONCLUSION: ZWFB capsule can promote energy metabolism and ATPase activity in the gastric mucosa cell, so as to protect the function of the gastric mucosa cell.

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期刊信息
  • 《新中医》
  • 北大核心期刊(2008版)
  • 主管单位:国家中医药管理局
  • 主办单位:广州中医药大学 中华中医药学会
  • 主编:
  • 地址:广州市番禹区广州大学城外环东路232号
  • 邮编:510006
  • 邮箱:xzybjb@gzhtcm.edu.cn
  • 电话:020-39359588
  • 国际标准刊号:ISSN:0256-7415
  • 国内统一刊号:ISSN:44-1231/R
  • 邮发代号:46-38
  • 获奖情况:
  • 全国优秀科技期刊,全国中医药优秀期刊,中国自然科学核心期刊,中国期刊方阵“双效”期刊
  • 国内外数据库收录:
  • 美国化学文摘(网络版),中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2000版)
  • 被引量:42405