中文摘要：

合成了一种具有双光子荧光探针功能的有机纳米粒子2,5,2＇,5＇-（4＇-N,N-二苯胺苯乙烯基）联苯（DPA-TSB）,并研究其细胞毒性.利用水溶性四氮唑（WST-1）法、乳酸脱氮酶（LDH）法和流式细胞术检测了胃癌细胞吞噬纳米粒子后的生理活性.研究结果表明,在纳米粒子浓度小于12μg/mL时,胃癌细胞仍表现出较好的生理活性,表明该纳米粒子是一种具有较好生物安全性的光功能有机纳米粒子.

英文摘要：

The cytotoxicity about organic nanoparticles which has the function of two-photon fluorescent probe 2,5,2′,5′-tetra（4′-N,N-diphenylaminostyryl）biphenyl（DPA-TSB） was studied.The physiological activity of stomach cancer cells after englobing the nanoparticle was detected by the methods of WAT-1,Lactate dehydrogenase（LDH） and flow cytometry.The results show that the stomach cancer cells can live well when the concentration of the nanoparticles is below 12 μg/mL,which suggests that the nanoparticles have the property of good biological security.