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中文摘要：
目的非洛地平纳米混悬液存在物理不稳定性，本实验旨在采用固化方法提高其物理稳定性。方法分别采用絮凝法和冷冻干燥法对非洛地平纳米混悬液进行固化。结果非洛地平纳米混悬液的平均粒径为151nm，呈单峰分布。絮凝后仅有76．7％小于1Ixm，且呈三峰分布；以20％甘露醇一甘氨酸（1：1，W／W）组对混悬剂的保护作用冻干效果最好，平均粒径在375nm左右的粒子占80％左右，其余粒径更小。结论选择冷冻干燥法固化非洛地平纳米混悬液，并且采用20％的甘露醇一甘氨酸（1：1，W／W）溶液为保护剂时，冻干效果最好。
英文摘要：
OBJECTIVE To solve the stability problem of felodipine nanosuspension which is a physically unstable colloidal dispersion by solidification method. METHODS Two different methods, flocculation and lyophilization, were applied to solidi- fy the felodipine nanosuspension. RESULTS The mean particle size of the felodipine nanosuspension was 151 nm and was uni- modally distributed, but only 76.7% particulates were smaller than 1 p,m following flocculation. For lyophilization, it was shown that 20% （W/V） of mannitol-glycine （ 1 ： 1, W/W） could stabilize the colloidal system best. CONCLUSION Lyophilization is considered to be superior to flocculation in the aspects of redispersed particle size, and 20% （W/V） of mannitol-glycine （ 1 ： I , W/W） is selected as the optimal cryoproteetant.
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