中文摘要：

脂肪细胞的增殖与分化异常是导致人类肥胖、心血管疾病和Ⅱ型糖尿病等的发生的主要原因,而3T3-L1前脂肪细胞是国际上公认的研究脂肪代谢的细胞模型,因此脂肪细胞的增殖与分化已成为研究的热点。本文主要论述3T3-L1前脂肪细胞的体外培养、增殖与分化及调控及其在功能性成分的评价中的应用,以期为预防和治疗肥胖及糖尿病等并发症提供一定的理论参考。

英文摘要：

The anomaly of adipocyte proliferation and differentiation plays a key role in the development of obesity,cardiovascular disease and non-insulin-dependent diabetes.3T3-L1 preadipocyte is a well-accepted model cell for study on adipogenesis.Recently the proliferation and differentiation of adipocytes have become a hot research topic.In this paper,the in vitro culture of 3T3-L1 preadipocyte,mechanisms regulating 3T3-L1 preadipocyte proliferation and differentiation and the application thereof in the evaluation of functional components are reviewed with the purpose to provide some references for the prevention and therapy of obesity and diabetes mellitus.