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Enantioselective Alkynylation of Ketones Promoted by β-Sulfonamide Alcohol-Titanium Complexes
  • ISSN号：1001-604X
  • 期刊名称：《中国化学：英文版》
  • 时间：0
  • 分类：O621.255.8[理学—有机化学;理学—化学]
  • 作者机构：[1]State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China, [2]Department of Biology, Hubei Normal University, Huangshi, Hubei 435002, China, [3]State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu 730000, China
  • 相关基金：Project suported by the National Natural Science Foundation of China （Nos. 20372028, 20472026, 20525206, 20021001） and the Specialized Research Fund for the Doctoral Program in Higher Education Institutions of the Ministry of Education of China.
作者： 倪明[1,2], 周益峰[1], 陈超[1], 许江珂[1], 王锐[2,3]
关键词： 酮, 对映体选择性烷基化, β-磺胺醇, 钛配合物, ketone, asymmetric, alkynylation, β-sulfonamide alcohol, catalysis
中文摘要：

容易地可得到的硫安类药剂白酒钛建筑群被发现在把 alkynylzinc 试剂的不对称的增加反应提升到 unactivated 上有效在很温和的条件下面的简单酉同类。并且相应 chiral 第三级的 propargylic 白酒与多达 86% 的 enantiomeric 过量被获得，它提供了一个简单、实际、便宜的方法产生 chiral 第三级的 propargylic 白酒。

英文摘要：

A readily available β-sulfonamide alcohol-titanium complex was found to be effective on promoting the asymmetric addition reaction of an alkynylzinc reagent to unactivated simple ketones under very mild conditions. And the corresponding chiral tertiary propargylic alcohols were obtained with enantiomeric excesses of up to 86%, which provided a simple, practical and inexpensive method to generate chiral tertiary propargylic alcohols.

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期刊信息
  • 《中国化学：英文版》
  • 主管单位:
  • 主办单位:中国化学会
  • 主编：
  • 地址：上海市枫林路354号中科院上海有机化学研究所
  • 邮编：200032
  • 邮箱：
  • 电话：021-54925243
  • 国际标准刊号：ISSN：1001-604X
  • 国内统一刊号：ISSN：31-1547/O6
  • 邮发代号:4-646
  • 获奖情况:
  • 中国期刊方阵“双高”期刊
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,英国英国皇家化学学会文摘
  • 被引量:175