中文摘要：

冠状血管为心脏提供营养及氧供,对心脏的正常工作至关重要。冠状血管的管壁主要由平滑肌细胞及内皮细胞构成,平滑肌细胞的结构和功能对冠状血管及心脏的正常工作有重要影响。控制细胞分化、迁移及平滑肌前体细胞数量的分子通路决定了冠状血管的结构及容量。这些信号通路的异常会导致血管畸形,故了解这些机制有益于利用前体细胞进行体内细胞重排从而诱导血管再生。

英文摘要：

Coronary blood vessels is so important to the normal functioning of the heart for providing nutrients and oxygen. The wall of coronary blood vessel is made up of smooth muscle cells and endothelial cells. The structure and function of the coronary artery smooth muscle of coronary vessels can influence the normal functioning of the heart a lot. Molecular pathways that control the differentiation, migration, and the number of available smooth muscle progenitor cells play key roles in determining blood vessel size and structure. Defects in these pathways will produce malformations of developing blood vessels. A better understanding of the molecular mechanisms that uniquely specify and maintain vascular smooth muscle cell precursors is essential for utilizing progenitor cell biology for somatic cell reprogramming to induce the revascularization.