中文摘要：

通过开环聚合法制备了可在37℃下实现溶胶-凝胶相变的PCEC温敏水溶胶;采用原位交联聚合包埋技术将牛血清白蛋白（BSA）和壳聚糖（CS）包裹在凝胶中,进行体外缓释试验,并通过摩擦磨损试验测试了缓释液的润滑性能,采用SEM,AFM对磨损表面进行了检测分析。结果表明：载有BSA/CS的PCEC水凝胶在37℃条件下缓释35 d,BSA的累积释放量仅为凝胶所载BSA含量的15%;提取不同天数缓释液中,最大摩擦因数仅约为生理盐水的37%,为模拟体液的64%,为牛血清白蛋白溶液的82%;缓释液的摩擦因数随着载荷、往复频率的增加而降低,表现出较好的润滑性能,且缓释液在摩擦副表面形成的蛋白吸附,有效降低了摩擦副材料的磨损。

英文摘要：

Thermosensitive PCEC hydrogel was synthesized by a ring-opening polymerization method, reacting in situ phase transition at 37 ℃. Bovine serum albumin （BSA） and chitosan （CS） were wrapped in gel by using crosslinking polymerization embedding technology to perform in vitro slow-release test. The tribological performance of slow-release lubricant carried by PCEC hydrogel was tested by friction and wear tests, and the wear surface is analyzed by SEM and AFM. The results reveal that the total releasing amount of BSA is only 15% of the amount of BSA in gel before the slow-release test by slow releasing for 35 days. Under the same friction condition, the friction coefficient of the slow release liquid is stable, and the maximum frictional coefficient of the slow-release liquid is only about 37% of the saline, 64% of the simulated body fluids, and 82% of the bovine serum albumin solution. The friction coefficient of the slow-release liquid decreases with increasing load and reciprocating frequency. The adsorption of protein on the surface of the sample can effectively reduce the friction and wear of the artificial joint material.